Searchable abstracts of presentations at key conferences in endocrinology

ea0034p283 | Pituitary | SFEBES2014

A deficit of dystrophin 71 leads to disorder in vasopressin and oxytocin production in the magnocellular neurons

Benabdesselam Roza , Dorbani-Mamine Latifa , Rendon Alvaro , Hardin-Pouzet Helene

Vasopressin (VP) and oxytocin (OT), the antidiuretic and natriuretic hormone, respectively, maintain the osmotic homeostasis. These molecules are synthesized in the magnocellular neurons (MCNs) of the supraoptic nuclei (SON) in the hypothalamus, transported via the axons toward the neural lobe of hypophysis (NLH) and released into the blood stream.Dp71 is the major form of dystrophins in the SON and NLH, where it was located in the glial-end-feet and end...